You are planning a genotype-disease association study. For genotypic measures, you have been advised to use a standard panel that interrogates

Question -You are planning a genotype-disease association study. Forgenotypic measures, you have been advised to use a standard panel that interrogates genotypes defined by 3 Million human SNPs. If you work at the usual 5% nominal level of significance (alpha=0.05), how many statistically significant false positive associations can you expect? -What are implications for sample size of a study if nominal level of significance is far less that 0.05? In other words, assuming power held steady, how would sample size needed to conduct a study using alpha=0.00000001 compare to the sample size needed to conduct a study using alpha=0.05? Health Science Science Nursing EPI 1906 Share QuestionEmailCopy link Comments (0)